Resources: Mammalian Cell Reprogramming Core

The NYSTEM-funded Mammalian Cell Reprogramming Core facility consists of 2 parts:

1) The centerpiece is the new Induced Pluripotent Stem Cell (iPS) Core Laboratory, located on the 9th floor of the Veterinary Research Tower. This newly established Core will have the capability to derive embryonic-like stem cells (iPS cells) from a variety of mammalian species including laboratory rodents and veterinary animals such as dogs and horses. This laboratory has a dedicated technician (Christian Abratte) who will : 1) develop and quality-control the material for stem cell work, 2) derive, grow and cryopreserve iPS cells from diverse species being studies by interested scientists, and 3) train students and scientists to use the cells for various applications. The Core is self-sufficient and fully-equipped for iPS work, and is supervised by John Schimenti.

2) The Stem Cell Genomics and Bioinformatics Unit is intended for modern, high-throughput genomic analysis of iPS cells, ES cells and adult stem cells to help fully understand how reprogramming and/or differentiation occurs. One key component is a "next generation" Solexa/Illumina Genome Analyzer (DNA sequencer). This has been installed in Cornell's DNA sequencing core lab, and is prioritized for stem cell-related projects. The second component is a full time bioinformatician (to start in October 2009) who has been hired to to help scientists and students interpret and analyze the vast amounts of data generated by various types of genomics experiments.