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NAME EMAIL DEPARTMENT RESEARCH INTERESTS
Carrie Adler
Research Assistant Professor

cea88@cornell.edu Molecular Medicine
We study stem cells and regeneration in planarian flatworms. Detailed description
We study stem cells and regeneration in planarian flatworms. Planarians can regenerate entire animals after amputation by activating pluripotent stem cells to produce new organs. We are interested in identifying the molecular mechanisms regulating stem cell behavior during regeneration. <<
Charles F. "Chip" Aquadro
Professor

cfa1@cornell.edu Molecular Biology and Genetics; Ecology and Evolutionary Biology
Molecular evolution and function of reproductive proteins in Drosophila and mammals; germ line stem cells Detailed description
We have for over a decade been studying (often in collaboration with Prof. Mariana Wolfner) the molecular evolution and function of reproductive proteins in Drosophila and mammals. The focus has been largely on proteins involved in fertilization and that are transferred to the female during copulation, many of which are surprisingly rapidly evolving. More recently, we have studied the molecular evolution of genes involved in germline stem cell maintenance and differentiation to form gametes. We have discovered that several of the key GSC genes in Drosophila evolve at an extraordinarily rapid rate due to natural selection protein divergence between species. The functional consequences, and evolutionary mechanisms generating, this rapid protein evolution of critical GCS genes is now a significant focus of our research efforts and carried out in collaboration with Prof. Daniel Barbash. Our studies include population genetic analyses, as well as cell, developmental and reproductive assessments of function using site-specific interspecific gene transformation, and the evaluation of functional interactions with intracellular microbes, pathogens, viruses and transposable elements. <<
Daniel Barbash
Professor

dab87@cornell.edu Molecular Biology and Genetics
We study Drosophila germ-line stem cell function and evolution. Some genes involved in germ-line stem differentiation show surprisingly high evolutionary rates in their protein-coding sequences. Detailed Description
We study Drosophila germ-line stem cell function and evolution. Some genes involved in germ-line stem differentiation show surprisingly high evolutionary rates in their protein-coding sequences. This discovery suggests that germ-line stem cells may face a continual challenge of adapting to external pathogens and internal genomic parasites such as transposable elements. In collaboration with Prof. Charles (Chip) Aquadro we are investigating the functional consequences of this gene evolution. We have additional research projects addressing the functional evolution of heterochromatin and heterochromatin-binding proteins, which also have important implications for understanding the repressive environment required to maintain stem cells. <<
Lawrence Bonassar
Professor
lb244@cornell.edu Biomedical Engineering & Mechanical & Aerospace Eng.
Our laboratory focuses on the use of marrow-derived mesenchymal stem cells for skeletal tissue regeneration. Detailed Description
Our laboratory focuses on the use of marrow-derived mesenchymal stem cells for skeletal tissue regeneration. We are particularly interested in identifying mechanical stimuli that are chondrogenics for stem cells and in factors that regulate mechanical adhesion of stem cells to connective tissue. <<
Nicolas Buchon
Assistant Professor
nicolas.buchon@cornell.edu Entomology
Control of intestinal stem cell behavior in homeostasis and disease Detailed Description
The intestinal epithelium is the tissue that displays the fastest turnover in the organism. In addition to its digestive function, the gut also faces the highest density of bacteria of the whole organism. We study how intestinal stem cells are regulated in the gut of Drosophila, and how epithelial integrity affects their activity. We analyze the impact of indigenous and pathogenic microbes on stem cell behavior and the molecular cross talks between immunity and tissue repair mechanisms.<<
Jonathan Butcher
Associate Professor
jtb47@cornell.edu Biomedical Engineering
Regenerative strategies involving mesenchymal and embryonic stem cells & roles of mechanical forces in the regulation of heart valve cell and tissue biology Detailed Description
We seek to understand the microenvironmental cues in embryonic development that guide precursor cells toward mature phenotypes in the heart. The objective is to use this paradigm to drive the differentiation of autologously accessible stem populations toward these unique phenotypes for regenerative/therapeutic applications. <<
Jonathan Cheetham
Associate Professor
jc485@cornell.edu Clinical Sciences
Understanding the immune response to peripheral nerve injury and modulating this response to improve functional recovery.
Paula Cohen
Professor
pc242@cornell.edu Biomedical Sciences
Mammalian meiosis; RNA binding Argonauts in germline and other mammalian tissue stem cells Detailed Description
The Cohen lab is interested in the regulation of mammalian meiosis and germ cell development. Our research is primarily focused on the control of meiotic recombination by DNA repair proteins, but extending from that, we are interested in how post-meiotic gern cells acquire and maintain competence to undergo fertilization. <<

Scott Coonrod
Professor

sac269@cornell.edu Biomedical Sciences and Baker Institute for Animal Health
Epigenetic regulation of preimplantation development and embryonic fate decisions Detailed Description
Once ovulated, the terminally differentiated mammalian oocyte will die if it does not bind and fuse with a sperm. If fertilization occurs, however, maternal gene products orchestrate the transformation of the egg into a totipotent zygote within hours. My lab is investigating the role that novel, highly-abundant, and egg-restricted molecules play in this reprogramming process. Additionally, we are also investigating the role of maternal epigenetic modifiers (and the histone modifications that they catalyze) in gene regulation in the egg and preimplantation embryo. <<

Benjamin Cosgrove
Assistant Professor

bdc68@cornell.edu Biomedical Engineering
We develop and utilize systems bioengineering approaches to study the cell-fate regulatory mechanisms underlies the decline of stem cell function and tissue regeneration in aging and disease. Detailed Description
We develop and utilize systems bioengineering approaches to study the cell-fate regulatory mechanisms underlies the decline of stem cell function and tissue regeneration in aging and disease. Specifically, we use quantitative single-cell assays and models to interrogate the cell signaling and communication networks controlling adult muscle stem cell self-renewal. <<

Charles Danko
Assistant Professor

dankoc@gmail.com Biomedical Sciences and Baker Institute for Animal Health
Our work focuses on understanding how gene expression contributes to cell-fate specification during differentiation. Detailed Description
We track naive CD4+ T-cells using genome-wide approaches (especially PRO-seq) as they are locked into either a Treg or Th17 cell fate. This work serves as a unique model for understanding differentiation and cell fate specification. <<
Longying (Lynn) Dong
Director, Immunopathology R & D Lab
ld295@cornell.edu Molecular Biology and Protein Biochemistry
My lab provides a wide range of technical services to the department and external research organizations on and off campus in immunohistochemical (IHC) techniques including immunoperoxidase and immunofluorescence IHC, in situ hybridization, and TUNEL in a variety of species of fixed / frozen tissue, and cultured cells including embryonic or adult stem cells. Detailed Description
My lab provides a wide range of technical services to the department and external research organizations on and off campus in immunohistochemical (IHC) techniques including immunoperoxidase and immunofluorescence IHC, in situ hybridization, and TUNEL in a variety of species of fixed / frozen tissue, and cultured cells including embryonic or adult stem cells. The lab also provides services for preparation and cryosectioning of frozen tissues. With prior experience with stem cell research, I am very interested in all possible collaborations to develop markers for analyzing and characterizing the embryonic stem cells including iPS cells. <<
Maria Julia Felippe
Associate Professor, Director of Veterinary Curriculum
mbf6@cornell.edu Clinical Sciences
Mechanisms of regulation of B cell differentiation using equine bone marrow- and fetal liver-derived hematopoietic stem cells Detailed Description
We have been studying a late-onset B cell immunodeficiency in the horse that causes B cell depletion from primary and secondary lymphoid tissues. Affected adult horses present recurrent bacterial infections and lack of antibody production. We have been investigating mechanisms of regulation of B cell differentiation using equine bone marrow- and fetal liver-derived hematopoietic stem cells; in addition, we have efforts toward creating a horse-mouse chimera so we can populate equine B cells in SCID mice starting from these hematopoietic stem cells. Our goal is to identify the cause of this disease and a treatment for it. <<
Claudia Fischbach-Teschl
Associate Professor
cf99@cornell.edu Biomedical Engineering
Role of microenvironmental conditions in the malignant regulation of stem cell behavior Detailed Description
Stem cells have the ability to directly or indirectly promote tumor malignancy. Our lab utilizes biomedical engineering strategies to model specific microenvironmental conditions that may play a critical role in regulating the tumor-promoting potential of these cells by controlling their self-renewal, differentiation, and secretory behavior. <<
Andrea Flesken-Nikitin
Research Assistant Professor
af78@cornell.edu Biomedical Sciences
My long-term research interests are focused on understanding of the ovarian carcinoma pathogenesis. Detailed Description
It is well established that many cancers arise from stem cells. However, little is known about stem cells of the female reproductive tract. To address this shortcoming I identify and characterize cancer-prone stem cell niches in the ovarian and tubal epithelia by using mouse models and primary human tissues. <<
Lisa Fortier
Professor
laf4@cornell.edu Clinical Sciences
iPS, bone marrow stem cells, and cartilage repair Detailed Description
The Fortier laboratory focuses on refining the clinical application of stem cells for treatment of orthopaedic diseases. The two main clinical areas of interest are in cartilage and ligament regeneration. The goal is to use cell surface and epigenetic modification markers to identify the optimal subpopulation of stem cells for therapeutic applications. <<
Kenneth Kemphues
Professor
kjk1@cornell.edu Molecular Biology & Genetics
Patterning in early development of C. elegans; establishment of polarity; asymmetric cell division in totipotent cells Detailed Description
We study the establishment of polarity in the early C. elegans embryo. This occurs through a series of stem-cell like divisions; the zygote divides asymmetrically producing a somatic cell and a germ-line stem cell. The germ-line stem cell divides asymmetrically three more times generating three more somatic cells and a single germ-line primordial cell. Our research focuses on the mechanistic basis for the asymmetric division of the germ-line stem cells. <<
Amnon Koren
Assistant Professor
koren@cornell.edu Molecular Biology & Genetics
Genomics of human DNA replication timing and mutagenesis Detailed Description
We develop experimental and computational approaches for studying DNA replication timing in large numbers of human cell lines; study how DNA replication timing influences mutation rates and patterns in human somatic cells and germ cells; and investigate how replication programs are altered in cancer and in various genetic diseases. We are currently studying DNA replication timing in a large cohort of human embryonic stem cells, particularly with respect to variations in DNA replication timing among cell types and among people. We are utilizing these cells for functional studies of DNA replication timing using CRISPR-mediated gene disruption and stem cell differentiation. <<
Michael Kotlikoff
Provost, Professor
mik7@cornell.edu CU Administration & Biomedical Sciences
Molecular processes underlying cardiac stem cell and smooth muscle cell development and function Detailed Description
The Kotlikoff lab is using stem cells to repair the injured heart. Current cell -based therapies result in modest improvement in heart function, but also risks electrical dysfunction. Experiments see to transfer cells that persist within the damage myocardium and are electrically coupled to the normal heart tissue. <<
Natasza A. Kurpios
Assistant Professor
nk378@cornell.edu Pharmacology, Genetics and Development, and Molecular and Integrative Physiology
To understand the role of of Pea3 in mammary epithelial stem cells our laboratory takes advantage of mouse genetics and the mammary transplantation assay to determine the downstream cellular effectors of Pea3 signaling during mammary gland development. Detailed Description
The Ets transcription factor Pea3 is overexpressed in breast tumors suggesting that it plays a role in mammary oncogenesis. In the normal mammary gland, Pea3 is expressed in the epithelium of the mouse mammary anlagen commensurate with their genesis and in the stem and progenitor cells of the adult mammary gland. To understand the role of of Pea3 in mammary epithelial stem cells our laboratory takes advantage of mouse genetics and the mammary transplantation assay to determine the downstream cellular effectors of Pea3 signaling during mammary gland development. <<
Jan Lammerding
Associate Professor
jan.lammerding@cornell.edu Biomedical Engineering
Investigate the role of nuclear envelope proteins in stem cell differentiation Detailed Description
Mutations in the nuclear envelope proteins lamin A and C cause a plethora of human diseases, primarily affecting mesenchymal tissues. The work in our laboratories is aimed at exploring the molecular mechanisms responsible for these diseases. One of our research areas is to investigate whether altered expression or localization of nuclear envelope proteins can modulate stem cell differentiation, either by directly interfering with gene regulation or by disrupting the structural organization of the cell/nucleus. <<
S. Sylvia Lee
Professor
ssl29@cornell.edu Molecular Biology & Genetics
Genetics of aging; Role of HCF1 and HCF1 longevity determinants in stem cells Detailed Description
Our laboratory is interested in elucidating the molecular basis of longevity using C. elegans and mammalian models. One of our research areas is to investigate how germline stem cells affect longevity in C. elegans. In addition, we plan to investigate how stem cell functions may be altered during aging in various mouse longevity mutants. <<
Sergiy Libert
Assistant Professor
libert@cornell.edu Biomedical Sciences
Development of novel methods to use genetically modified autologous neuronal stem cells to treat neurodegenerative diseases, such as ALS.
John Lis
Professor
jtl10@cornell.edu Molecular Biology & Genetics
Molecular biology and genomics of gene regulation in embryonic stem cells Detailed Description
The Lis lab's interest lies in identifying genome-wide transcriptional activities in embryonic stem cells to help understand the transcription networks and the regulatory steps critical for the maintenance and differentiation of stem cells. As a first step, they are applying their recently developed approach for examining genome-wide distributions of engaged RNA polymerase II (Pol II) by global run-on assays and Solexa sequencing in mammalian cells, which provides unique snapshots of all transcriptionally-engaged RNA Pol II over the entire genome, including actively elongating Pol II and regulatory, promoter-proximal paused Pol II. These complete transcriptional signatures will help understand regulatory differences between pluripotent and differentiated cells at the molecular level and provide a framework for exploring the combinations of transcription factors that permit faithful reprogramming of the differentiated cells to an embryonic stem cell state, and that direct differentiation of embryonic stem cells to specialized cell types. <<
Jun Kelly Liu
Professor
jl53@cornell.edu Molecular Biology & Genetics
Molecular genetics of cell fate specification and diversification; In vivo cellular reprogramming Detailed Description
We are interested in how multipotent progenitor cells proliferate and differentiate into distinct cell types. We are also using C. elegans as a model system to explore in vivo cellular reprogramming.<<
Dan Luo
Professor
dl79@cornell.edu Biological and Environmental Engineering
Our nanobarcodes can be used for multiplexed detection including in situ FISH, and our DNA hydrogels can be employed to culture stem cells in a 3D fashion with a total control over pore sizes, shapes and internal contents. Detailed Description
Our lab focuses on using DNA as a general material building block. We have created novel DNA-based materials including dendrimers, nanobarcodes, and hydrogels that are made entirely from branched DNA through enzymatic reactions. More relevant to the stem cell community, our nanobarcodes can be used for multiplexed detection including in situ FISH. Our DNA hydrogels can be employed to culture stem cells in a 3D fashion with a total control over pore sizes, shapes and internal contents. In addition, the DNA gel is capable of producing proteins without any living organisms. <<
Minglin Ma
Assistant Professor
mm826@cornell.edu Biological and Environmental Engineering
Encapsulation of hESC-derived pancreatic progenitors for type 1 diabetes treatment.
John March
Associate Professor
jcm224@cornell.edu Biological and Environmental Engineering
Our lab's interest in Stem Cell research is linked to our interest in improving in vitro models of the upper GI tract. Detailed Description
Our lab's interest in stem cell research is linked to our interest in improving in vitro models of the upper GI tract. We are working to make a model of the GI tract that includes crypt cells grown in 3D culture. Our efforts are in collaboration with Dan Luo's group who is working with DNA gel scaffolds for growing our cells. Ultimately we want to use our 3D cultures to study interactions between commensal bacteria and the upper intestine. <<
Andrew Miller
Assistant Professor
adm10@cornell.edu Biomedical Sciences
Defining the stem cell niches in spontaneously arising tumors in the dog and laboratory animal species.
Alexander Nikitin
Professor
an58@cornell.edu Biomedical Sciences
Role of stem cell compartment in carcinogenesis, mouse models, stem cell pathology Detailed Description
Understanding how molecular and cellular mechanisms controlling normal stem cells may be involved in malignant transformation is essential for development of better regenerative medicine approaches, as well as for advances in our understanding of cancer pathogenesis. Our laboratory focuses on elucidation of mechanisms by which tumor suppressor genes, microRNAs and microenvironmental factors control embryonic and adult stem cells and how aberrations in these mechanisms may lead to cancer. <<
Nozomi Nishimura
Assistant Professor
nn62@cornell.edu Biomedical Engineering
We are interested in how stem cells contribute to recovery after injuries. Detailed Description
We are interested in how stem cells contribute to recovery after injuries. We develop optical tools such as imaging and ablation for tracking cells after lesions in several in vivo mouse systems. In the intestinal crypt, we study how the numbers and patterns of stem cells and their neighboring cells recover from perturbations.<<
Alan Nixon
Professor
ajn1@cornell.edu Clinical Sciences
Mesenchymal stem cells in chondrogenesis and cartilage repair Detailed Description
Adult stem cells can be isolated, propagated, and programmed to facilitate musculoskeletal repair. This work involves transcriptional profiling of MSC and EPCs, gene directed differential pathway switching, and combinatorial approaches to transposon based stem cell transduction and cytokine suppression within orthopedic repair tissues. <<
Andrea Quaroni
Professor
aq10@cornell.edu Biomedical Sciences
Identification and characterization of stem cells in the adult small intestinal epithelium, focusing on cell surface markers and gene expression by microarray analysis.
Kristy Richards
Associate Professor
kristy.richards@cornell.edu Biomedical Sciences
Our lab studies mechanisms of lymphomagenesis in both animals and humans. Detailed Description
Often, cancer cells hijack and activate developmental pathways to obtain immortaility and to gain increased replicative capacity. This leads to stem-cell like properties in cancer cells, which is reflected in lymphoma gene expression profiles and mutation spectra. One example we are currently studying is the role of FOXP1 (usually a developmental transcription factor that is not expressed in mature lymphoid cells, but overexpressed in a subset of lymphomas) as an activator of WNT pathway signaling in lymphoma. <<
Veerle Rottiers
Research Scientist
rottiers@cornell.edu Molecular Biology & Genetics
We use the worm, C. elegans, to study how the removal of germline stem cells increases the lifespan in a sex-specific manner. Detailed Description
Like many stem cell systems, the C. elegans germ line contains a self-renewing germ cell population that is maintained by a niche. Interestingly, specific removal of the proliferating germline stem cells (GSCs) in the gonad of C. elegans hermaphrodites robustly increases their lifespan while male lifespan is not changed. We are using metabolomic and genetic tools to investigate the changes that occur (or fail to occur) upon germ cell stem cell loss in hermaphrodites and males and determine the nature of the sex-specific differences in response to GSC loss. Such research will help us understand how changes in GSCs pools or different responses to signals from the germ cell stem affect the lifespan of organisms in a sex specific way.<<
Brian Rudd Assistant Professor bdr54@cornell.edu Microbiology & Immunology Determining how differences between fetal and adult hematopoietic stem cells influences the ability of individuals to respond to pathogens during early life.
Chris Schaffer
Associate Professor
cs385@cornell.edu Biomedical Engineering
Development of advanced optical imaging techniques used to follow the dynamics and interactions among different kinds of cells in animal models. Detailed Description
We develop advanced optical imaging techniques that are used to follow the dynamics and interactions among different kinds of cells in animal models, with a focus on developing an understanding of the cellular interactions in the central nervous system that drive neurodegenerative disease. These tools would be well suited to studies of stem cell behavior in animal models of regenerative therapies. We are particularly interested in imaging the behavior and activity of stem cells implanted into injured spinal cord to better understand their potential for driving regeneration. <<
John Schimenti
Professor
jcs92@cornell.edu Biomedical Sciences and Molecular Biology & Genetics
DNA Repair, cancer; genome instability; mouse genetics; germline stem cells; embryonic stem cells and induced pluripotent cells. Detailed Description
Stem-cell related research in my lab includes: 1) The identification of mouse genes involved in proliferation or maintenance of the germline stem cell pool; 2) study of a novel gene that is required for pre-implantation mouse development and is highly expressed in embryonic stem cells but is downregulated upon differentiation; and 3) use of embryonic stem cells as tools to identify novel genes required for germline stem cells. <<
Vimal Selvaraj
Assistant Professor
vs88@cornell.edu Animal Science
Our laboratory is interested in both basic and translational aspects of stem cell biology. Detailed Description
Our laboratory is interested in both basic and translational aspects of stem cell biology. By investigating early events in the activation of development after fertilization, we seek to understand the events leading to establishment of the pluripotency network and the genesis of embryonic stem cells in the developing blastocyst. We also study cues that guide the differentiation of pluripotent stem cells into oligodendrocyte precursors for cell therapy-based myelin regeneration in demyelinating diseases. <<
Praveen Sethupathy
Associate Professor
praveens@cornell.edu Biomedical Sciences
We are interested in the role of non-coding RNAs, especially microRNAs, in intestinal stem cell (ISC) function, particularly in response to environmental stimuli such as dietary factors, commensal microbes, and ingested pathogens.  Detailed Description
We are interested in the role of non-coding RNAs, especially microRNAs, in intestinal stem cell (ISC) function, particularly in response to environmental stimuli such as dietary factors, commensal microbes, and ingested pathogens. We are focused on microRNAs in mouse and human ISC biology, and have active collaborations with those studying invertebrate (fruit fly) ISCs. We also are interested in cancer stem cells, particularly in the context of fibrolamellar carcinoma, a rare stem cell-rich liver cancer for which the molecular etiology is very poorly understood.<<
Ankur Singh
Assistant Professor
as2833@cornell.edu Mechanical & Aerospace Engineering
My research focus is on understanding mouse/human stem cell reprogramming, differentiation, and engineering stem cells for therapeutic applications. Detailed Description
My research focus is on understanding mouse/human stem cell reprogramming, differentiation, and engineering stem cells for therapeutic applications. My recent work has been on understanding the changes in cell mechanics of human induced pluripotent stem cell undergoing reprogramming and differentiation to neural and cardiac lineages. In addition, I have experience is developing innovative technologies to study stem cell patterning (like embryonic patterns) and sort therapeutic cells. <<
Paul Soloway
Professor
pds28@cornell.edu Nutritional Science
Mammalian epigenetics; the epigenome of embryonic stem cells Detailed Description
We study the cis and trans acting factors that control reprogramming of epigenetic states in the mouse germ line. Our goal is to understand how epigenetic marks are established, maintained and propagated to other sites in the genome and how these mechanisms are influenced by environmental variables. <<
Teresa Southard
Associate Clinical Professor
tls93@cornell.edu Biomedical Sciences
I am an anatomic pathologist with a special interest in rodent pathology. I perform gross and microscopic examinations of animals and tissues in collaboration with researchers involved in stem cell-related projects.
Elia Tait Wojno
Assistant Professor
edt42@cornell.edu Microbiology & Immunology and Baker Institute for Animal Health
Immune responses and hematopoiesis during helminth infection and allergic disease Detailed Description
Immune responses and hematopoiesis during helminth infection and allergic disease, focusing on how cytokines and prostaglandins influence the differentiation of hematopoietic stem cells to various innate cell lineages in the context of type 2 immune responses at mucosal tissues. <<
Alexander Travis
Associate Professor
ajt32@cornell.edu Biomedical Sciences and Baker Institute for Animal Health
Biology of male germ cells and differentiation of germline stem cells Detailed Description
My laboratory investigates stem cell-based technologies to preserve genetic diversity and to manipulate the germline. Specifically, we study testis xenografting and spermatogonial stem cell transplantation in dog and cat models. Both techniques give the practical benefit of being able to produce sperm from genetically valuable donors. In addition, they also provide models for the study of spermatogonial stem cells and spermatogenesis, and provide an opportunity to generate transgenic animals as important biomedical models for human and animal disease. <<
Tudorita (Doina) Tumbar
Professor
tt252@cornell.edu Molecular Biology & Genetics
Molecular and cellular regulation of stem cell renewal and differentiation using mouse hair follicle as a model Detailed Description
Our laboratory is interested in elucidating the basic cellular and molecular mechanisms implicated in cell fate choice and stem cell activity within tissues. We focus on adult stem cells and their interaction with the tissue of residence, and use the mouse skin as a primary model system. Within the skin epithelia stem cells are thought to reside both in the outer epidermis and in a specialized area of the hair follicle called the bulge. The bulge is a stem cell niche thought to keep their potent resident cells in a differentiation and proliferation inhibited state. It allows external signals to selectively penetrate and instruct stem cells to migrate out and proliferate when they are needed: during the initiation of the hair follicle growth and in wounded, regenerating skin. Understanding the basic signaling pathways involved in regulating stem cells in their native tissue will help manipulate cells in culture for cell and tissue transplantation therapy. <<
Gerlinde R. Van de Walle
Assistant Professor
grv23@cornell.edu Baker Institute for Animal Health
Mammary gland and mesenchymal stem cells Detailed Description
Our stem cell research is focusing on two types of stem cells. On the one hand, we study mammary gland stem cells (MaSC) from different veterinary animal species to investigate the role of these cells in the development of mammary cancer. On the other hand we study the biological properties of equine mesenchymal stem cells (MSC) to characterize their potential in regenerative medicine in horses as well as in humans (the horse as a translational animal model).<<
Robert Weiss
Professor
rsw26@cornell.edu Biomedical Sciences
Genome maintenance mechanisms, cellular responses to genotoxins; mouse cancer models, DNA damage signaling, genomic instability; cancer stem cells Detailed Description
The Weiss lab develops mouse models to study (1) stem cell genome maintenance by DNA damage checkpoint mechanisms and (2) the origins and therapeutic sensitivity of testicular germ cell cancers. <<
Andrew White
Assistant Professor
acw93@cornell.edu Biomedical Sciences
We use mouse models to understand the causes and conditions that facilitate cancer initiation and progression arising from adult stem cells of the skin. Detailed Description
Our goal is to determine the necessary molecular steps that lead to the formation of a skin tumor and identify means through which we can interrupt this process to prevent cancer. Furthermore, we are interested in identifying points of potential targeted intervention on established tumors through both genetic and pharmacological methods.<<
Rebecca Williams
Research Scientist
rw36@cornell.edu Biomedical Engineering
Intravital multiphoton imaging of cancer initiation and progression in animal models.
Andrew Yen
Professor
ay13@cornell.edu Biomedical Sciences
Cell Cycle regulation, differentiation; retinoids and their regulation of pluripotency factors Detailed Description
We are studying the molecular mechanism of retinoic acid in control of the cell cycle and differentiation. Retinoic acid is a developmental morphogen that controls embryogenesis. We are studying how it controls the cellular decisions to proliferate or not and choose a specific differentiation lineage using an immature hematopoietic precursor cell to gain insight into the pathways that it governs. <<
Warren Zipfel
Associate Professor
wrz2@cornell.edu Biomedical Engineering
Intravital multiphoton imaging of cancer progression in animal models. Early events in transformation, tumor differentiation and extracellular signaling during tumor growth.

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